Current projects:
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AboutEDUCATION: 1999 B.S. in Radiology, Kaohsiung Medicine University, Taiwan 2001 M.S. in Radiology, National Yang-Ming University, Taipei 2008 Ph.D. in Pharmacology, National Yang-Ming University, Taipei HONORS AND AWARDS: 2007 Outstanding Award of the Annual Thesis Competition, National Yang-Ming University, Taiwan 2008 The third place Poster Award, Asia-Pacific Congress on Oral Cavity Cancer in Conjunction with the 12th Annual Meeting of Taiwan Cooperative Oncology Group 2011 Research Competition Award for Attending International Conference, Institute of Biomedical Sciences, Academia Sinica 2016 榮獲台灣藥理學會『104年度杜聰明博士年輕學者獎』 『台灣藥理學會-杜聰明博士年輕學者獎』為台灣藥理學會為鼓勵年輕會員學術研究風氣暨提昇研究水準所設置之獎項,每年獲獎名額一至二名。慈大藥理學科/藥毒碩博士班賴國筑老師即為『104年度杜聰明博士年輕學者獎』二位得獎者之一。 105/03/26於台北-105年生物醫學聯合學術年會之台灣藥理學會會員大會頒獎 EXPERIENCE: 2008-2012 Postdoctoral Fellow, Institute of Biomedical Sciences, Academia Sinica, Taiwan 2012-2016 Assistant Professor, Department of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan 2016-2020 Associate Professor, Department of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan 2020-until now Assistant Professor, Department of Physiology and Pharmacology, Chang Gung University, Taoyuan, Taiwan |
PUBLICATIONS
(A) Peer reviewed papers
(B) Abstracts
- Lai KC and Lee TC Genetic damage in cultured human keratinocytes stressed by long-term exposure to areca nut extracts. (2006) Mutat. Res.-Fundam. Mol. Mech. Mutagen., 599: 66-75.
- Lai KC, Chang KW, Liu CJ, Kao SY and Lee TC IFN-induced Protein with Tetratricopeptide Repeats 2 Inhibits Migration Activity and Increases Survival of Oral Squamous Cell Carcinoma. (2008) Mol. Cancer Res., 6:1431-1439.
- Hung KF, Lai KC, Liu TY, Liu CJ, Lee TC and Lo JF Asb6 upregulation by Areca nut extracts is associated with betel quid-induced oral carcinogenesis. (2009) Oral Oncol., 45:543-548.
- Lai KC, Liu CJ, Chang CK, and Lee TC Depleting IFIT2 mediates atypical PKC signaling to enhance the migration and metastatic activity of oral squamous cell carcinoma cells. (2013) Oncogene 32: 3686-3697.
- Lai KC, Liu CJ, Chang CK, Lee TC HSP70 Colocalizes with PLK1 at the Centrosome and Disturbs Spindle Dynamics in Cells Arrested in Mitosis by Arsenic Trioxide. (2014) Archives of Toxicology 88: 1711-1723.
- Lai KC, Liu CJ, Lin TJ, Mar AC, Wang HH, Chen CW, Hong ZX, Lee TC Blocking TNF-α Inhibits Angiogenesis and Growth of IFIT2-Depleted Metastatic Oral Squamous Cell Carcinoma Cells. (2016) Cancer Letters 370: 207-215.
- Patel AS, Jain V, Rao VN, Lin YW, Shah A, Lai KC, Su TL, Lee TC. Design, synthesis and antitumour evaluation of pyrrolo[1,2-f]-phenanthridine and dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives. EUR J MED CHEM. 2020. SEP; 202:112516.
- Lin TJ, Lai KC, Lee AS, Chang CH, Liu CL, Chung CH. Novel antrodia cinnamomea extract reduced cancer stem-Like phenotype changes and resensitized KRAS mutant colorecta cancer via a microRNA-27a pathway. CANCERS. 2019; 11:1657.
- Ku WT, Tung JJ, Lee Tony JF, Lai KC: Long-term exposure to oroxylin A inhibits metastasis by suppressing CCL2 in oral squamous cell carcinoma cells. CANCERS. 2019;11:353. (Corresponding author)
- Ku WT, Tung JJ, Lee Tony JF, Lai KC: Long-term exposure to oroxylin A inhibits metastasis by suppressing CCL2 in oral squamous cell carcinoma cells. CANCERS. 2019;11:353. (Corresponding author)
(B) Abstracts
- Lai KC, Chang KW, Liu CJ and Lee TC (2006). Enhanced expression of ASB6 and IFIT2 in oral squamous cell carcinoma. The 97th Annual Meeting of the American Association for Cancer Research, April 1 - 5, Washington, DC, USA.
- Lai KC, Chang KW, Liu CJ and Lee TC (2006). Enhanced expression of ASB6 and IFIT2 in oral squamous cell carcinoma. The 11th Taiwan Joint Cancer Conference, May 6 - 7, Taipei, ROC.
- Lai KC, Chang KW, Liu CJ and Lee TC (2007) Prognostic role of IFIT2 and its biological functions in oral squamous cell carcinoma. The 12th Taiwan Joint Cancer Conference and 6th Cross-Strait Academia Conference on Oncology, May 5 - 6, Taipei, ROC.
- Lai KC, Chang KW, Liu CJ, Kao SY and Lee TC (2008) IFIT2 protein inhibits migration activity and increases survival in oral squamous cell carcinoma. Asia-Pacific Congress on Oral Cavity Cancer in Conjunction with the 12th Annual Meeting of Taiwan Cooperative Oncology Group, Dec 6 - 7, Taipei, ROC.
- Lai KC, and Lee TC (2009) Elevated IFIT2 expression promotes oral squamous cell carcinoma differentiation. The 49th Annual Meeting of the American Society for Cell Biology, December 5-9, San Diego, CA, USA. (Support by NSC 98-2914-I-001-019-A1)
- Lai KC, Liu CJ and Lee TC (2011). IFIT2 depletion promotes migration through atypical PKC signaling in oral squamous cell carcinoma. American Association for Cancer Research 102nd Annual Meeting 2011, April 2-6, Orlando, Florida, USA. (Support by NSC 100-2914-I-001-004-A1)
- Lai KC, Liu CJ and Lee TC (2011). IFIT2 depletion promotes migration through atypical PKC signaling in oral squamous cell carcinoma. Taiwan Joint Cancer Conference, April 30-May 1, Taipei, ROC
- Yen AH, Lai KC, Chen YC, Liu CJ, Chang KW, and Lee TC. Association of interferon-induced protein with tetratricopeptide repeats 1 gene family with human papilloma virus infection in patients with oral squamous cell carcinoma. American Association for Cancer Research 104nd Annual Meeting 2013.
- Lai KC. (2016) Depleting IFIT2 enhances oral cancer metastasis via activation of aPKC and TNF pathways. BIT's 9th Annual World Cancer Congress-2016 May 14-May 16, Shanghai, China.